- The Haunted (#110) – Animal Planet @ 10/9c
- Funny or Die Presents (#101) – HBO @ 11:59/10:59c
- The Ricky Gervais Show (#101) – HBO @ 9/8c
- Real Time with Bill Maher (#801) – HBO @ 10/9c
- The Life & Times of Tim – HBO @ 9:30/8:30c
- Olympic Winter Games 2010 – NBC @ 8/7c (Night 8 of 17)
- American Loggers (#205) – Discovery Channel @ 10/9c
- Caprica (#105) – Syfy @ 9/8c
- Cribs (#C304) – CMT @ 10/9c
- Famous Crime Scene (#102-30) – VH1 @ 9/8c
- Friday Night with Jonathan Ross (#1805) – BBC America @ 9/8c
- Friday Night Alright (#107-30) – VH1 @ 11/10c
- I Shouldn’t Be Alive (#305) – Animal Planet @ 9/8c
- Jimmy Kimmel Live – ABC @ 1:36AM/12:36AMc
- Late Show with David Letterman – CBS @ 11:35/10:35c
- Peak Season: Vancouver (#106-30) – VH1 @ 11:30/10:30c
- Smallville – CW @ 8/7c
- Spartacus (#105) – Starz @ 10/9c
- The Best Thing I Ever Ate – Food Network @ 10/9c
- The Late Late Show with Craig Ferguson – CBS @ 1:37AM/12:37AMc
- The Singing Bee (#304-60) – CMT @ 9/8c
- The Soup – E! @ 10/9c
- What Not to Wear (#807) – TLC @ 9/8c
- *New* – Jimmy Kimmel Live @ 1:36AM/12:36AMc
- *New* – Late Show with David Letterman @ 11:35/10:35c
- *New* – The Late Late Show with Craig Ferguson @ 1:37AM/12:37AMc
- *New* – Smallville @ 8/7c
- *Special* – Olympic Winter Games 2010 @ 8/7c (Night 8 of 17)
- *New* – I Shouldn’t Be Alive (#305) @ 9/8c
- *Season Finale* – The Haunted (#110) @ 10/9c
- *New* – Friday Night with Jonathan Ross (#1805) @ 9/8c
- *New* – The Singing Bee (#304-60) @ 9/8c
- *New* – Cribs (#C304) @ 10/9c
- *New* – American Loggers (#205) @ 10/9c
- *New* – The Soup @ 10/9c
- *New* – The Best Thing I Ever Ate @ 10/9c
- *Series Premiere* – The Ricky Gervais Show (#101) @ 9/8c
- *Season Premiere* – The Life & Times of Tim @ 9:30/8:30c
- *Season Premiere* – Real Time with Bill Maher (#801) @ 10/9c
- *Series Premiere* – Funny or Die Presents (#101) @ 11:59/10:59c
- *New* – Spartacus (#105) @ 10/9c
- *New* – Caprica (#105) @ 9/8c
- *New* – What Not to Wear (#807) @ 9/8c
- *New* – Famous Crime Scene (#102-30) @ 9/8c
- *New* – Friday Night Alright (#107-30) @ 11/10c
- *New* – Peak Season: Vancouver (#106-30) @ 11:30/10:30c
- *Special* – Olympic Winter Games 2010 – NBC (Night 8 of 17)
- *New* – Smallville – CW
- *New* – Caprica (#105) – Syfy
- *New* – Famous Crime Scene (#102-30) – VH1
- *New* – Friday Night with Jonathan Ross (#1805) – BBC America
- *New* – I Shouldn’t Be Alive (#305) – Animal Planet
- *Series Premiere* – The Ricky Gervais Show (#101) – HBO
- *New* – The Singing Bee (#304-60) – CMT
- *New* – What Not to Wear (#807) – TLC
- *Season Premiere* – The Life & Times of Tim – HBO
- *New* – American Loggers (#205) – Discovery Channel
- *New* – Cribs (#C304) – CMT
- *Season Premiere* – Real Time with Bill Maher (#801) – HBO
- *New* – Spartacus (#105) – Starz
- *New* – The Best Thing I Ever Ate – Food Network
- *Season Finale* – The Haunted (#110) – Animal Planet
- *New* – The Soup – E!
- *New* – Friday Night Alright (#107-30) – VH1
- *New* – Late Show with David Letterman – CBS (11:35/10:35c)
- *New* – Peak Season: Vancouver (#106-30) – VH1
- *Series Premiere* – Funny or Die Presents (#101) – HBO (11:59/10:59c)
- *New* – Jimmy Kimmel Live – ABC (1:36AM/12:36AMc)
- *New* – The Late Late Show with Craig Ferguson – CBS (1:37AM/12:37AMc)