- Construction Intervention (#108) – Discovery Channel @ 7/6c
- The Neistat Brothers (#101) – HBO @ 11:59/10:59c
- Flashpoint (#301) – CBS @ 9/8c
- Whale Wars (#301) – Animal Planet @ 9/8c
- The 2010 Scripps National Spelling Bee – ABC @ 8/7c (2-Hour Special)
- Danger Coast (#109) – CMT @ 9:30/8:30c
- Friday Night with Jonathan Ross (#1818) – BBC America @ 10:20/9:20c
- Friday Night Lights (#405) – NBC @ 8/7c
- Gator 911 (#109) – CMT @ 9/8c
- Gavin & Stacey (#304) – BBC America @ 9/8c
- Gravity (#107) – Starz @ 10:30/9:30c
- Merlin (#209) – Syfy @ 10/9c
- Miami Medical – CBS @ 10/9c
- Not Going Out (#304) – BBC America @ 9:40/8:40c
- Party Down (#207) – Starz @ 10/9c
- Past Life (#PLF-104) – FOX @ 8/7c
- Real Time with Bill Maher (#815) – HBO @ 10/9c
- Say Yes To the Dress (#509/510) – TLC @ 9/8c & 9:30/8:30c (2 New Episodes)
- Stargate Universe (#119) – Syfy @ 9/8c
- The Late Late Show with Craig Ferguson – CBS @ 1:37AM/12:37AMc
- The Soup – E! @ 10/9c
- *Special* – The 2010 Scripps National Spelling Bee @ 8/7c (2-Hour Special)
- *Season Premiere* – Flashpoint (#301) @ 9/8c
- *New* – Miami Medical @ 10/9c
- *New* – The Late Late Show with Craig Ferguson @ 1:37AM/12:37AMc
- *New* – Past Life (#PLF-104) @ 8/7c
- *New* – Friday Night Lights (#405) @ 8/7c
- *Season Premiere* – Whale Wars (#301) @ 9/8c
- *New* – Gavin & Stacey (#304) @ 9/8c
- *New* – Not Going Out (#304) @ 9:40/8:40c
- *New* – Friday Night with Jonathan Ross (#1818) @ 10:20/9:20c
- *New* – Gator 911 (#109) @ 9/8c
- *New* – Danger Coast (#109) @ 9:30/8:30c
- *New* – Real Time with Bill Maher (#815) @ 10/9c
- *Series Premiere* – The Neistat Brothers (#101) @ 11:59/10:59c
- *New* – Party Down (#207) @ 10/9c
- *New* – Gravity (#107) @ 10:30/9:30c
- *New* – Stargate Universe (#119) @ 9/8c
- *New* – Merlin (#209) @ 10/9c
- *New* – Say Yes To the Dress (#509/510) @ 9/8c & 9:30/8:30c (2 New Episodes)
- *Season Finale* – Construction Intervention (#108) – Discovery Channel
- *New* – Friday Night Lights (#405) – NBC
- *New* – Past Life (#PLF-104) – FOX
- *Special* – The 2010 Scripps National Spelling Bee – ABC (2-Hour Special)
- *Season Premiere* – Flashpoint (#301) – CBS
- *New* – Gator 911 (#109) – CMT
- *New* – Gavin & Stacey (#304) – BBC America
- *New* – Say Yes To the Dress (#509/510) – TLC (2 New Episodes)
- *New* – Stargate Universe (#119) – Syfy
- *Season Premiere* – Whale Wars (#301) – Animal Planet
- *New* – Danger Coast (#109) – CMT
- *New* – Not Going Out (#304) – BBC America (9:40/8:40c)
- *New* – Say Yes To the Dress (#509/510) – TLC (2 New Episodes)
- *New* – Friday Night with Jonathan Ross (#1818) – BBC America (10:20/9:20c)
- *New* – Merlin (#209) – Syfy
- *New* – Miami Medical – CBS
- *New* – Party Down (#207) – Starz
- *New* – Real Time with Bill Maher (#815) – HBO
- *New* – The Soup – E!
- *New* – Gravity (#107) – Starz
- *Series Premiere* – The Neistat Brothers (#101) – HBO (11:59/10:59c)
- *New* – The Late Late Show with Craig Ferguson – CBS (1:37AM/12:37AMc)